Corpus de fidélité empirique
La liste publique des 50 publications utilisées pour mesurer la fidélité du scoring (ÉNS, distribution gaussienne neutre, μ=50, σ=20).
Méthodologie en vigueur : v2.0.0 (depuis le 21/10/2026)
Qu'est-ce qu'une version de méthodologie ?
Pour mesurer la fidélité de chaque mode, nous utilisons un corpus public et stable de publications thématiques (47 aujourd'hui, cible 50). Distribution alignée sur la cible théorique (gaussienne neutre, μ=50, σ=20) : 5A / 14B / 9C / 14D / 5E + 3 retracted (X) — l'écart observé/cible est affiché tel quel, jamais comblé en déplaçant un seuil.
Pourquoi un corpus figé ? Pour que la fidélité empirique soit reproductible : si nous changeons la grille ou un évaluateur, nous re-mesurons sur le même corpus → l'écart est mesurable, pas opinable.
Pourquoi 47 publications pour la distribution / 34 publications appariées ?
Sur les 47 publications du corpus, 34 disposent d'une référence PDF complet (IA) mesurable. Les 13 autres sont scorées à partir de l'abstract (IA) parce que leur PDF est verrouillé derrière le paywall NEJM, Lancet, JAMA ou autres grandes revues qui n'imposent pas de dépôt en accès libre. La mesure de concordance publiée (badges de fidélité) a été établie en mai 2026 sur 28 publications appariées ; elle sera remesurée au prochain rejeu sur les publications appariées actuelles.
Cette asymétrie n'est pas un défaut, c'est un choix méthodologique délibéré qui reflète la science médicale réelle : la médecine clinique de pointe est largement publiée dans des revues paywallées. Construire un corpus 100% paired aurait introduit un biais de sélection vers l'open access pur (BMJ, PLOS, Cochrane) et rendu inatteignable une distribution réaliste des paliers — la plupart des publications palier A étant précisément parues dans NEJM/Lancet.
Conséquence opérationnelle : la distribution paliers (cible 5A/14B/9C/14D/5E/3X) est calculée sur les 47 publications, et la fidélité empirique (concordance Abstract (IA) vs PDF complet, concordance Métadonnées (Rapide) vs PDF complet) sur les publications appariées. Les deux mesures restent honnêtes parce qu'elles répondent à deux questions différentes : « le corpus reflète-t-il la science médicale ? » et « les modes scorent-ils de manière cohérente entre eux ? ».
Limite assumée : la mesure de concordance publiée (mai 2026) ne comptait aucune publication palier A appariée — les paliers A sont rares et largement publiés dans des revues paywallées. Cette limite est une propriété structurelle de l'écosystème éditorial scientifique — pas un choix arbitraire de notre part.
Distribution observée vs cible théorique
(ÉNS, distribution gaussienne neutre, μ=50, σ=20)
| A | B | C | D | E | X | |
|---|---|---|---|---|---|---|
| Distribution cible | 5 | 14 | 9 | 14 | 5 | 3 |
| Observé | 2 | 14 | 9 | 14 | 5 | 3 |
Les 47 publications du corpus
| Palier | Score | PMID | Titre | Journal | Année | Mode | Paired | Thématique | Signal |
|---|---|---|---|---|---|---|---|---|---|
| A | 78 | 32445440 | Remdesivir for the Treatment of Covid-19 - Final Report. | The New England journal of medicine | 2020 | PDF complet (IA) | ✓ | COVID-treatments | |
| A | 76 | 33627334 | Statin treatment and muscle symptoms: series of randomised, placebo controlled n-of-1 trials. | BMJ (Clinical research ed.) | 2021 | PDF complet (IA) | ✓ | Cardio | |
| B | 69 | 33205991 | Effectiveness of Adding a Mask Recommendation to Other Public Health Measures to Prevent SARS-CoV-2 Infection in Danish Mask Wearers : A Randomized Controlled Trial. | Annals of Internal Medicine | 2020 | PDF complet (IA) | ✓ | Infectious | |
| B | 68 | 18303940 | Initial severity and antidepressant benefits: a meta-analysis of data submitted to the Food and Drug Administration. | PLOS Medicine | 2008 | PDF complet (IA) | ✓ | MentalHealth | |
| B | 68 | 33882225 | Safety and Efficacy of Single-Dose Ad26.COV2.S Vaccine against Covid-19. | The New England Journal of Medicine | 2021 | PDF complet (IA) | ✓ | COVID-vaccines | |
| B | 66 | 29388196 | Vaccines for preventing influenza in healthy adults. | The Cochrane Database of Systematic Reviews | 2018 | PDF complet (IA) | ✓ | MetaEpistemo | |
| B | 64 | 26099233 | Antibiotics for acute otitis media in children. | Cochrane Database of Systematic Reviews | 2015 | PDF complet (IA) | ✓ | Infectious | |
| B | 64 | 35854107 | The serotonin theory of depression: a systematic umbrella review of the evidence. | Molecular Psychiatry | 2022 | PDF complet (IA) | ✓ | MentalHealth | |
| B | 63 | 40760353 | Ultraprocessed or minimally processed diets following healthy dietary guidelines on weight and cardiometabolic health: a randomized, crossover trial. | Nature Medicine | 2025 | PDF complet (IA) | ✓ | Endocrino | |
| B | 61 | 24519768 | Twenty five year follow-up for breast cancer incidence and mortality of the Canadian National Breast Screening Study: randomised screening trial. | BMJ | 2014 | PDF complet (IA) | ✓ | Onco | |
| B | 61 | 31255301 | Population-level impact and herd effects following the introduction of human papillomavirus vaccination programmes: updated systematic review and meta-analysis. | Lancet (London, England) | 2019 | PDF complet (IA) | ✓ | Infectious | |
| B | 60 | 34020944 | Nonreplicable publications are cited more than replicable ones. | Science Advances | 2021 | PDF complet (IA) | ✓ | MetaEpistemo | |
| B | 60 | 36715243 | Physical interventions to interrupt or reduce the spread of respiratory viruses. | The Cochrane database of systematic reviews | 2023 | PDF complet (IA) | ✓ | Infectious | |
| B | 58 | 22998339 | A randomized trial of sugar-sweetened beverages and adolescent body weight. | New England Journal of Medicine | 2012 | PDF complet (IA) | ✓ | Nutrition | |
| B | 58 | 41326666 | Liraglutide in mild to moderate Alzheimer's disease: a phase 2b clinical trial. | Nature Medicine | 2025 | PDF complet (IA) | ✓ | Neurology | |
| B | 56 | 21091279 | Preexposure chemoprophylaxis for HIV prevention in men who have sex with men. | The New England journal of medicine | 2010 | PDF complet (IA) | ✓ | Clinical | |
| C | 54 | 20233825 | Stereotactic body radiation therapy for inoperable early stage lung cancer. | JAMA | 2010 | PDF complet (IA) | ✓ | Onco | |
| C | 52 | 26187233 | A 2-Year Randomized Controlled Trial of Human Caloric Restriction: Feasibility and Effects on Predictors of Health Span and Longevity. | The Journals of Gerontology: Series A | 2015 | PDF complet (IA) | ✓ | Cardio | |
| C | 50 | 40634782 | Plasma proteomics links brain and immune system aging with healthspan and longevity. | Nature Medicine | 2025 | PDF complet (IA) | ✓ | Neurology | |
| C | 49 | 33306989 | Safety and efficacy of the ChAdOx1 nCoV-19 vaccine (AZD1222) against SARS-CoV-2: an interim analysis of four randomised controlled trials in Brazil, South Africa, and the UK. | The Lancet | 2021 | PDF complet (IA) | ✓ | Infectious | |
| C | 49 | 34278372 | Impact of original, B.1.1.7, and B.1.351/P.1 SARS-CoV-2 lineages on vaccine effectiveness of two doses of COVID-19 mRNA vaccines: Results from a nationwide case-control study in France. | Lancet Regional Health – Europe | 2021 | PDF complet (IA) | ✓ | Infectious | |
| C | 48 | 25244186 | Ebola virus disease in West Africa--the first 9 months of the epidemic and forward projections. | The New England journal of medicine | 2014 | PDF complet (IA) | ✓ | Infectious | |
| C | 48 | 31621801 | Circulating Tumor DNA Analyses as Markers of Recurrence Risk and Benefit of Adjuvant Therapy for Stage III Colon Cancer. | JAMA oncology | 2019 | PDF complet (IA) | ✓ | Onco | |
| C | 47 | 31922679 | A network meta-analysis of the effects of psychotherapies, pharmacotherapies and their combination in the treatment of adult depression. | World Psychiatry | 2020 | PDF complet (IA) | ✓ | MentalHealth | |
| C | 46 | 40839273 | GLP-1 Receptor Agonists and Cancer Risk in Adults With Obesity. | JAMA Oncology | 2025 | PDF complet (IA) | ✓ | Onco | |
| D | 44 | 41270766 | Ultra-processed foods and human health: the main thesis and the evidence. | Lancet (London, England) | 2025 | PDF complet (IA) | ✓ | Nutrition | |
| D | 43 | 18635428 | Weight loss with a low-carbohydrate, Mediterranean, or low-fat diet. | New England Journal of Medicine | 2008 | Abstract (IA) | — | Nutrition | |
| D | 41 | 16060722 | Why most published research findings are false. | PLoS medicine | 2005 | PDF complet (IA) | ✓ | MetaEpistemo | |
| D | 41 | 32015508 | A new coronavirus associated with human respiratory disease in China. | Nature | 2020 | PDF complet (IA) | ✓ | Infectious | |
| D | 41 | 35116013 | SARS-CoV-2 Vaccination and Protection Against Clinical Disease: A Retrospective Study, Bouches-du-Rhône District, Southern France, 2021. | Frontiers in Microbiology | 2022 | PDF complet (IA) | ✓ | Infectious | |
| D | 40 | 23413192 | Multiple instances of ancient balancing selection shared between humans and chimpanzees. | Science (New York, N.Y.) | 2013 | PDF complet (IA) | ✓ | Clinical | |
| D | 39 | 33835769 | Thrombotic Thrombocytopenia after ChAdOx1 nCov-19 Vaccination. | The New England Journal of Medicine | 2021 | PDF complet (IA) | ✓ | COVID-vaccines | |
| D | 37 | 15328324 | Sugar-sweetened beverages, weight gain, and incidence of type 2 diabetes in young and middle-aged women. | JAMA | 2004 | Abstract (IA) | — | Nutrition | |
| D | 33 | 31986264 | Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China. | Lancet (London, England) | 2020 | PDF complet (IA) | ✓ | Infectious | |
| D | 31 | 10376617 | Autism and measles, mumps, and rubella vaccine: no epidemiological evidence for a causal association. | Lancet | 1999 | Abstract (IA) | — | COVID-vaccines | |
| D | 31 | 23159055 | The Salmonella kinase SteC targets the MAP kinase MEK to regulate the host actin cytoskeleton. | Cell Host Microbe | 2011 | Abstract (IA) | — | Infectious | |
| D | 31 | 28322183 | The UN Decade of Nutrition, the NOVA food classification and the trouble with ultra-processing. | Public Health Nutrition | 2017 | PDF complet (IA) | ✓ | Nutrition | |
| D | 31 | 32459046 | Scientific and Standardization Committee communication: Clinical guidance on the diagnosis, prevention, and treatment of venous thromboembolism in hospitalized patients with COVID-19. | Journal of thrombosis and haemostasis : JTH | 2020 | PDF complet (IA) | ✓ | Infectious | |
| D | 27 | 12421889 | A population-based study of measles, mumps, and rubella vaccination and autism. | N Engl J Med | 2001 | Abstract (IA) | — | COVID-vaccines | |
| E | 25 | 33864435 | How Children and Youth with Medical Complexity Use Hospital and Emergency Department Care across Canada. | Healthcare Quarterly | 2021 | Abstract (IA) | — | Clinical | |
| E | 24 | 10917215 | Serum procalcitonin, C-reactive protein and interleukin-6 for distinguishing bacterial and viral pneumonia in children. | The Pediatric Infectious Disease Journal | 1999 | Abstract (IA) | — | Infectious | |
| E | 24 | 24508041 | Association of the use of MMRV in infants by pediatric infectious disease specialists with that of other affiliated providers. | Vaccine | 2013 | Abstract (IA) | — | COVID-vaccines | |
| E | 23 | 32516120 | [Programming and reprogramming from conception till death]. | New England Journal of Medicine | 2020 | Abstract (IA) | — | Clinical | |
| E | 23 | 38658043 | General practice management after transition events: protocol for an experience-based co-design study. | BJGP open | 2024 | Abstract (IA) | — | MetaEpistemo | |
| X | 0 | 9500320 | Ileal-lymphoid-nodular hyperplasia, non-specific colitis, and pervasive developmental disorder in children. | Lancet | 1998 | Abstract (IA) | — | COVID-vaccines | Retracté |
| X | 0 | 23432189 | Primary prevention of cardiovascular disease with a Mediterranean diet. | New England Journal of Medicine | 2013 | Abstract (IA) | — | Nutrition | Retracté |
| X | 0 | 32356626 | Cardiovascular Disease, Drug Therapy, and Mortality in Covid-19. | The New England Journal of Medicine | 2020 | Abstract (IA) | — | Cardio | Retracté |
Légende des colonnes
- Mode : méthode utilisée pour scorer cette publication. PDF complet (IA) = analyse du texte intégral ; Abstract (IA) = résumé seul ; Métadonnées (IA) = titre/journal/auteurs sans résumé ; Saisie humaine = scoring manuel via formulaire.
- Apparié : ✓ si la publication est utilisée dans la mesure de concordance entre modes (référence PDF complet disponible). — sinon (PDF sous paywall, mesuré sur son propre palier seulement).
Données brutes
Les 47 fichiers de scoring sont disponibles publiquement dans le dépôt source ouvert. Chaque fichier contient, pour une publication, son score détaillé, le détail par critère, le coefficient d'intégrité et les justifications de l'IA. La mesure de fidélité est entièrement reproductible et gratuite à partir de ces fichiers.