Corpus de fidélité empirique
La liste publique des 50 articles utilisés pour mesurer la fidélité du scoring (ÉNS, distribution gaussienne neutre, μ=50, σ=20).
Méthodologie en vigueur : v1.1 (depuis le 17/05/2026)
Qu'est-ce qu'une version de méthodologie ?
Pour mesurer la fidélité de chaque mode, nous utilisons un corpus public et stable de 50 articles thématiques. Distribution alignée sur la cible théorique (gaussienne neutre, μ=50, σ=20) : 5A / 14B / 9C / 14D / 5E + 3 retracted (X).
Pourquoi un corpus figé ? Pour que la fidélité empirique soit reproductible : si nous changeons la grille ou un évaluateur, nous re-mesurons sur le même corpus → l'écart est mesurable, pas opinable.
Pourquoi 50 articles distribution / 28 articles paired ?
Sur les 50 articles du corpus, 29 disposent d'une référence PDF complet (IA) mesurable et 28 sont effectivement utilisés pour la mesure de concordance (un article exclu pour abstract trop court). Les 21 autres sont scorés à partir de l'abstract (IA) parce que leur PDF est verrouillé derrière le paywall NEJM, Lancet, JAMA ou autres grandes revues qui n'imposent pas de dépôt en accès libre.
Cette asymétrie n'est pas un défaut, c'est un choix méthodologique délibéré qui reflète la science médicale réelle : la médecine clinique de pointe est largement publiée dans des revues paywallées. Construire un corpus 100% paired aurait introduit un biais de sélection vers l'open access pur (BMJ, PLOS, Cochrane) et rendu inatteignable une distribution réaliste des paliers — la plupart des articles palier A étant précisément publiés en NEJM/Lancet.
Conséquence opérationnelle : la distribution paliers (5A/14B/9C/14D/5E/3X) est calculée sur les 50, et la fidélité empirique (concordance Abstract (IA) vs PDF complet, concordance Métadonnées (Rapide) vs PDF complet) est calculée sur les 28 articles appariés. Les deux mesures restent honnêtes parce qu'elles répondent à deux questions différentes : « le corpus reflète-t-il la science médicale ? » et « les modes scorent-ils de manière cohérente entre eux ? ».
Limite assumée : la mesure de concordance ne couvre pas les articles palier A du corpus (tous abstract-only). Cette limite est une propriété structurelle de l'écosystème éditorial scientifique — pas un choix arbitraire de notre part.
Distribution observée vs cible théorique
(ÉNS, distribution gaussienne neutre, μ=50, σ=20)
| A | B | C | D | E | X | |
|---|---|---|---|---|---|---|
| Distribution cible | 5 | 14 | 9 | 14 | 5 | 3 |
| Observé | 5 | 14 | 9 | 14 | 5 | 3 |
Les 50 articles du corpus
| Palier | Score | PMID | Titre | Journal | Année | Mode | Paired | Thématique | Signal |
|---|---|---|---|---|---|---|---|---|---|
| A | 85 | 21767103 | Prevention of HIV-1 infection with early antiretroviral therapy. | The New England journal of medicine | 2011 | PDF complet (IA) | ✓ | Clinical | |
| A | 83 | 29388196 | Vaccines for preventing influenza in healthy adults | The Cochrane Database of Systematic Reviews | 2018 | PDF complet (IA) | ✓ | MetaEpistemo | |
| A | 81 | 31255301 | Population-level impact and herd effects following the introduction of human papillomavirus vaccination programmes: updated systematic review and meta-analysis. | Lancet (London, England) | 2019 | PDF complet (IA) | ✓ | Infectious | |
| A | 81 | 33627334 | Statin treatment and muscle symptoms: series of randomised, placebo controlled n-of-1 trials. | BMJ (Clinical research ed.) | 2021 | PDF complet (IA) | ✓ | Cardio | |
| A | 79 | 40760353 | Ultraprocessed or minimally processed diets following healthy dietary guidelines on weight and cardiometabolic health: a randomized, crossover trial | Nature Medicine | 2025 | PDF complet (IA) | ✓ | Endocrino | |
| B | 75 | 36715243 | Physical interventions to interrupt or reduce the spread of respiratory viruses. | The Cochrane database of systematic reviews | 2023 | PDF complet (IA) | ✓ | Infectious | |
| B | 73 | 31922679 | A network meta-analysis of the effects of psychotherapies, pharmacotherapies and their combination in the treatment of adult depression | World Psychiatry | 2020 | PDF complet (IA) | ✓ | MentalHealth | |
| B | 71 | 26099233 | Antibiotics for acute otitis media in children | Cochrane Database of Systematic Reviews | 2015 | PDF complet (IA) | ✓ | Infectious | |
| B | 68 | 26187233 | A 2-Year Randomized Controlled Trial of Human Caloric Restriction: Feasibility and Effects on Predictors of Health Span and Longevity | The Journals of Gerontology: Series A | 2015 | PDF complet (IA) | ✓ | Cardio | |
| B | 68 | 40634782 | Plasma proteomics links brain and immune system aging with healthspan and longevity | Nature Medicine | 2025 | PDF complet (IA) | ✓ | Neurology | |
| B | 67 | 26378978 | Empagliflozin, Cardiovascular Outcomes, and Mortality in Type 2 Diabetes. | New England Journal of Medicine | 2015 | PDF complet (IA) | ✓ | Cardio | |
| B | 66 | 35854107 | The serotonin theory of depression: a systematic umbrella review of the evidence | Molecular Psychiatry | 2022 | PDF complet (IA) | ✓ | MentalHealth | |
| B | 62 | 18303940 | Initial severity and antidepressant benefits: a meta-analysis of data submitted to the Food and Drug Administration. | PLOS Medicine | 2008 | PDF complet (IA) | ✓ | MentalHealth | |
| B | 62 | 33205991 | Effectiveness of Adding a Mask Recommendation to Other Public Health Measures to Prevent SARS-CoV-2 Infection in Danish Mask Wearers | Annals of Internal Medicine | 2020 | PDF complet (IA) | ✓ | Infectious | |
| B | 61 | 21091279 | Preexposure chemoprophylaxis for HIV prevention in men who have sex with men. | The New England journal of medicine | 2010 | PDF complet (IA) | ✓ | Clinical | |
| B | 59 | 41326666 | Liraglutide in mild to moderate Alzheimer's disease: a phase 2b clinical trial | Nature Medicine | 2025 | PDF complet (IA) | ✓ | Neurology | |
| B | 58 | 24519768 | Twenty five year follow-up for breast cancer incidence and mortality of the Canadian National Breast Screening Study: randomised screening trial | BMJ | 2014 | PDF complet (IA) | ✓ | Onco | |
| B | 58 | 32015508 | A new coronavirus associated with human respiratory disease in China | Nature | 2020 | PDF complet (IA) | ✓ | Infectious | |
| B | 56 | 34020944 | Nonreplicable publications are cited more than replicable ones | Science Advances | 2021 | PDF complet (IA) | ✓ | MetaEpistemo | |
| C | 55 | 37952131 | Semaglutide and Cardiovascular Outcomes in Obesity without Diabetes | The New England Journal of Medicine | 2023 | PDF complet (IA) | ✓ | Cardio | |
| C | 53 | 34278372 | Effectiveness of an mRNA COVID-19 vaccine among French nursing home residents | Lancet Regional Health – Europe | 2021 | PDF complet (IA) | ✓ | Infectious | |
| C | 53 | 40839273 | GLP-1 Receptor Agonists and Cancer Risk in Adults With Obesity | JAMA Oncology | 2025 | PDF complet (IA) | ✓ | Onco | |
| C | 51 | 20233825 | Stereotactic body radiation therapy for inoperable early stage lung cancer. | JAMA | 2010 | PDF complet (IA) | ✓ | Onco | |
| C | 51 | 31986264 | Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China. | Lancet (London, England) | 2020 | PDF complet (IA) | ✓ | Infectious | |
| C | 50 | 33306989 | Safety and efficacy of the ChAdOx1 nCoV-19 vaccine (AZD1222) against SARS-CoV-2: an interim analysis of four randomised controlled trials in Brazil, South Africa, and the UK | The Lancet | 2021 | PDF complet (IA) | ✓ | Infectious | |
| C | 48 | 32284615 | The proximal origin of SARS-CoV-2. | Nature medicine | 2020 | PDF complet (IA) | ✓ | Infectious | |
| C | 47 | 22998339 | A randomized trial of sugar-sweetened beverages and adolescent body weight. | New England Journal of Medicine | 2012 | PDF complet (IA) | ✓ | Nutrition | |
| C | 46 | 35249272 | Covid-19 Vaccine Effectiveness against the Omicron (B.1.1.529) Variant. | The New England journal of medicine | 2022 | PDF complet (IA) | ✓ | Infectious | |
| D | 44 | 21639808 | Improved survival with vemurafenib in melanoma with BRAF V600E mutation. | The New England journal of medicine | 2011 | PDF complet (IA) | ✓ | Onco | |
| D | 44 | 23413192 | Multiple instances of ancient balancing selection shared between humans and chimpanzees. | Science (New York, N.Y.) | 2013 | PDF complet (IA) | ✓ | Clinical | |
| D | 44 | 29262275 | Tumor Mutational Burden and Response Rate to PD-1 Inhibition. | The New England journal of medicine | 2017 | PDF complet (IA) | ✓ | Onco | |
| D | 44 | 33301246 | Safety and Efficacy of the BNT162b2 mRNA Covid-19 Vaccine | New England Journal of Medicine | 2020 | PDF complet (IA) | ✓ | Infectious | |
| D | 43 | 33545094 | Safety and efficacy of an rAd26 and rAd5 vector-based heterologous prime-boost COVID-19 vaccine: an interim analysis of a randomised controlled phase 3 trial in Russia. | Lancet (London, England) | 2021 | PDF complet (IA) | ✓ | Infectious | |
| D | 41 | 31621801 | Circulating Tumor DNA Analyses as Markers of Recurrence Risk and Benefit of Adjuvant Therapy for Stage III Colon Cancer. | JAMA oncology | 2019 | PDF complet (IA) | ✓ | Onco | |
| D | 39 | 16060722 | Why most published research findings are false. | PLoS medicine | 2005 | PDF complet (IA) | ✓ | MetaEpistemo | |
| D | 38 | 32521345 | How can airborne transmission of COVID-19 indoors be minimised? | Environment international | 2020 | PDF complet (IA) | ✓ | Infectious | |
| D | 35 | 28322183 | The UN Decade of Nutrition, the NOVA food classification and the trouble with ultra-processing | Public Health Nutrition | 2017 | PDF complet (IA) | ✓ | Nutrition | |
| D | 35 | 33961695 | β-d-N4-hydroxycytidine Inhibits SARS-CoV-2 Through Lethal Mutagenesis But Is Also Mutagenic To Mammalian Cells | The Journal of Infectious Diseases | 2021 | PDF complet (IA) | ✓ | Infectious | |
| D | 34 | 35116013 | SARS-CoV-2 Vaccination and Protection Against Clinical Disease: A Retrospective Study, Bouches-du-Rhône District, Southern France, 2021 | Frontiers in Microbiology | 2022 | PDF complet (IA) | ✓ | Infectious | |
| D | 33 | 32459046 | Scientific and Standardization Committee communication: Clinical guidance on the diagnosis, prevention, and treatment of venous thromboembolism in hospitalized patients with COVID-19. | Journal of thrombosis and haemostasis : JTH | 2020 | PDF complet (IA) | ✓ | Infectious | |
| D | 29 | 20089734 | Saturated fat, carbohydrate, and cardiovascular disease. | The American journal of clinical nutrition | 2010 | PDF complet (IA) | ✓ | Cardio | |
| D | 28 | 16115318 | Chloroquine is a potent inhibitor of SARS coronavirus infection and spread. | Virology journal | 2005 | PDF complet (IA) | ✓ | Infectious | |
| E | 25 | 35045295 | A bidirectional competitive interaction between circHomer1 and Homer1b within the orbitofrontal cortex regulates reversal learning. | Cell reports | 2022 | Abstract (IA) | — | MentalHealth | |
| E | 23 | 17240006 | B cell mediated priming following pneumococcal colonization | Vaccine | 2006 | Abstract (IA) | — | Clinical | |
| E | 20 | 29253145 | Noncommunicable Diseases in People Living With HIV: Time for Integrated Care | J Infect Dis | 2016 | Abstract (IA) | — | Infectious | |
| E | 12 | 32516120 | Programming and reprogramming from conception till death | New England Journal of Medicine | 2020 | Abstract (IA) | — | Clinical | |
| E | 11 | 34469921 | Ivermectin for Prevention and Treatment of COVID-19 Infection: A Systematic Review, Meta-analysis, and Trial Sequential Analysis to Inform Clinical Guidelines. | American journal of therapeutics | 2021 | PDF complet (IA) | ✓ | Infectious | |
| X | 0 | 23432189 | Primary prevention of cardiovascular disease with a Mediterranean diet | New England Journal of Medicine | 2013 | Abstract (IA) | — | Nutrition | Retracté |
| X | 0 | 32356626 | Cardiovascular Disease, Drug Therapy, and Mortality in Covid-19. | The New England Journal of Medicine | 2020 | Abstract (IA) | — | Cardio | Retracté |
| X | 0 | 34796244 | Meta-analysis of Randomized Trials of Ivermectin to Treat SARS-CoV-2 Infection | Open Forum Infectious Diseases | 2021 | PDF complet (IA) | ✓ | Infectious | Retracté |
Légende des colonnes
- Mode : méthode utilisée pour scorer cet article. PDF complet (IA) = analyse du texte intégral ; Abstract (IA) = résumé seul ; Métadonnées (IA) = titre/journal/auteurs sans résumé ; Saisie humaine = scoring manuel via formulaire.
- Apparié : ✓ si l'article est utilisé dans la mesure de concordance entre modes (référence PDF complet disponible). — sinon (PDF sous paywall, mesuré sur son propre palier seulement).
Données brutes
Les 50 fichiers de scoring sont disponibles publiquement dans le dépôt source ouvert. Chaque article contient son score détaillé, le détail par critère, le coefficient d'intégrité et les justifications de l'IA. La mesure de fidélité est entièrement reproductible et gratuite à partir de ces fichiers.