Thrombectomy 6 to 24 Hours after Stroke with a Mismatch between Deficit and Infarct

Abstract (PubMed)

206 patients with ischemic stroke (ICA/proximal MCA occlusion, last seen well 6–24h earlier, clinical-infarct mismatch) randomized to thrombectomy + standard care vs standard care alone. Trial stopped early at 31 months (interim analysis). Utility-weighted mRS 5.5 vs 3.4 (difference 2.0, 95% CrI 1.1–3.0, posterior probability >0.999). Functional independence at 90 days 49% vs 13%. No significant difference in symptomatic intracranial hemorrhage (6% vs 3%) or mortality (19% vs 18%). Funded by Stryker Neurovascular (DAWN).