⚡ Interrogation des APIs scientifiques en cours…
⚡ Interrogation des APIs scientifiques en cours…
Authors' conclusion
Does not affect the score
Publi-Score
Fidelity
Abstract (PubMed)
No effective prophylactic or post-exposure therapy for SARS-CoV is currently available. We report that chloroquine has strong antiviral effects on SARS-CoV infection of primate cells. These inhibitory effects are observed when cells are treated either before or after exposure to the virus, suggesting both prophylactic and therapeutic advantage. Chloroquine appears to interfere with terminal glycosylation of the cellular receptor ACE2, negatively influencing virus-receptor binding. EC50 (post-infection): 4.4 ± 1.0 μM. Chloroquine is effective in preventing SARS-CoV spread at clinically admissible concentrations.
Coeff. authors = avg(1.00, 1.00) = 1.00
Coeff. editorial = avg(0.80, 0.90) = 0.85
min(1.00, 0.85) = 0.85← lowest dominates
Final coefficient : 0.85
Final score = 30.8/100 × 0.85 × 100 = 26/100
Meta-analysis of Randomized Trials of Ivermectin to Treat SARS-CoV-2 Infection
Hill A — 2021 · Open Forum Infectious Diseases
Contrasted resultsEffect of Hydroxychloroquine in Hospitalized Patients with Covid-19
Horby P — 2020 · The New England journal of medicine
Contrasted resultsCardiovascular Disease, Drug Therapy, and Mortality in Covid-19.
Mehra MR — 2020 · The New England Journal of Medicine
Contrasted resultsA Trial of Lopinavir-Ritonavir in Adults Hospitalized with Severe Covid-19.
Cao B — 2020 · The New England journal of medicine
Contrasted resultsA new coronavirus associated with human respiratory disease in China
Wu F — 2020 · Nature